Search results for "Pulmonary Vascular Diseases"

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Isolated Lung Perfusion as an Adjuvant Treatment of Colorectal Cancer Lung Metastases: A Preclinical Study in a Pig Model

2012

BackgroundThe lung is a frequent site of colorectal cancer (CRC) metastases. After surgical resection, lung metastases recurrences have been related to the presence of micrometastases, potentially accessible to a high dose chemotherapy administered via adjuvant isolated lung perfusion (ILP). We sought to determine in vitro the most efficient drug when administered to CRC cell lines during a short exposure and in vivo its immediate and delayed tolerance when administered via ILP.MethodsFirst, efficacy of various cytotoxic molecules against a panel of human CRC cell lines was tested in vitro using cytotoxic assay after a 30-minute exposure. Then, early (operative) and delayed (1 month) tolera…

OncologyCardiothoracic SurgeryPathologyLung NeoplasmsSwineColorectal cancerIsolated lung perfusionmedicine.medical_treatmentCancer TreatmentCardiovascularDeoxycytidineMetastasischemistry.chemical_compoundDrug DistributionMultidisciplinaryQRThoracic SurgeryPerfusionTreatment OutcomeSurgical Oncologymedicine.anatomical_structureOncologyChemotherapy AdjuvantMedicineDeoxycytidineColorectal NeoplasmsAdjuvantResearch ArticleDrugs and Devicesmedicine.medical_specialtyScienceAntineoplastic AgentsIn vivoCell Line TumorInternal medicinemedicineAnimalsHumansPulmonary Vascular DiseasesPharmacokineticsAnalysis of VarianceChemotherapyLungDose-Response Relationship Drugbusiness.industryHemodynamicsChemotherapy and Drug Treatmentmedicine.diseaseGemcitabineDrug LiberationchemistryVasoconstrictionSurgerybusinessPLoS ONE
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